Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0098c16 | Clinical – Chemo/SSA/Biologics | NANETS2023

Comparison of well-differentiated gastroenteropancreatic grade 3 neuroendocrine tumors (G3NETS): de novo and in the setting of apparent grade progression over time

Khuong Le Bryan , Paciorek Alan , Moon Farhana , Lawhn Heath Courtney , Hope Thomas , Fidelman Nicholas , Mulvey Claire , Lindsay Sheila , Zhang¬ Li , Nakakura Eric , Joseph Nancy , Bergsland Emily K.

Background: G3NETs demonstrate variable clinical behavior (Ki-67>20-100%). Treatment extrapolated from grade 1/2 (G1/2) NETs and neuroendocrine carcinomas depending on clinicopathologic features. Therapy for treatment-emergent G3NETs remains especially ill-defined.Methods: Retrospective chart review of patients with de novo G3NETs or progressing from low-to-high grade (L-H) (G1/2 at diagnosis and G3 >=3 months later). Treatment patterns compared ...
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ea0098c37 | Clinical – Nuclear Medicine/Interventional Radiology/Imaging | NANETS2023

Initial Experience Using 0.55T MRI for Detection of Liver Metastases in NET Patients

Remick Isabelle , Armstrong Hope Thomas , Ohliger Michael , William Hong Cheng , Yang Yang , Bergsland Emily , Lawhn Heath Courtney , Su Pan , Itriago-Leon Pedro

Background: 0.55T MRI is a new MRI technology offering increased patient accessibility with a wider bore (80cm) and reduced acoustic noise. We compared the sensitivity of liver metastases detection on gadoxetate-enhanced 0.55T MRI to 68Ga-DOTATATE PET/CT while evaluating patient experience.Methods: Nine patients with neuroendocrine liver metastases were imaged using gadoxetate-enhanced 0.55T MRI (MAGNETOM Free.Max, Siemens Healthineers, Erlang...
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ea0098t1 | Trials In Progress | NANETS2023

ACTION-1: A randomized Phase Ib/3 trial of RYZ101 compared with SoC in SSTR+ well-differentiated GEP-NET with progression following Lu-177 SSA

Hope Thomas A. , Halperin Daniel , Strosberg Jonathan , Jacene Heather , E.T. Tesselaar Margot , Kunz Pamela L. , Ferreira Denis , Li Joanne , Ma Kimberly , Rearden Jessica , Moran Susan , Singh Simron

Background: Well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are commonly characterized by high-density expression of somatostatin receptors (SSTRs), which can be targeted by radiopharmaceutical therapy (RPT) via radiolabeled somatostatin analogues (SSAs). RYZ101 (225Ac-DOTATATE) is a first-in-class, highly potent alpha-emitting RPT being developed for the treatment of SSTR+ solid tumors. Alpha-particles (such as those emitted by 225<...
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ea0089t6 | Trials In Progress | NANETS2022

ACTION-1: A Randomized Phase Ib/3 trial of RYZ101 Compared with SoC in SSTR2+ Well-Differentiated GEP-NET with Progression Following Lu-177 SSA

Hope Thomas , Mehr Samuel , Morris Michael , Li Daneng , Halperin, MD Daniel , Strosberg Jonathan , Soares Heloisa , Jacene Heather , Pavel Marianne , L. Kunz Pamela , Ferreira Denis , Li Joanne , Ma Kimberly , Rearden Jessica , Moran Susan , Singh Simron

Background: Well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are commonly characterized by overexpression of somatostatin receptor subtype 2 (SSTR2), which can be targeted by radiopharmaceutical therapy (RPT) via radiolabeled somatostatin analogues (SSAs). RYZ101 (Ac-225 DOTATATE) is a first-in-class, highly potent alpha-emitting RPT being developed for the treatment of SSTR2+ solid tumors. Alpha-particles (such as emitted by Actinium-225) have a sho...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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